As 1000001101000 said, the thing with the 128mb cluster size is display value only, I doubt it would cause any access or speed issues.
On the speed issues, this unit is a home user device, I have a 220 myself and worked on a few others and all got into trouble if more than 2 clients access them at any given time. It's not the fastest in the first place and multiple users can easily push it to its limits. GUI gets really sluggish, transfer speeds go down, worst case you get timeouts/disconnects if too much is going on. I get around 40MB/s r/w on SMB2 if I am lucky (with one client connected), most of the time its less. Don't get me wrong, the unit is ok (and good value) for what its made for, but putting it into a company network with multiple clients is not the best idea.
Now you did mention it worked fine initially, so my guess here would be a) more users b) more data written/read within any given timeframe or c) hard drive. Less likely, but still possible, would be some firmware/settings issue, to rule those out you can simply reset it from the interface (it won't hurt the data as long as you select initialize and NOT erase/format)). Nevertheless, do a backup beforehand.