I haven’t tried on this specific device though I have on a similarish one (ls-qvl). There is a hard 16TB volume limit, I beleive this is corresponds to a 32-bit address space * 4k blocks but don’t quote me on it.
I would expect with 10tb drives on a 32-bit arm device you could operate in a non-raid or possibly raid1 configuration but raid 0/5/6/10/etc would cause problems.
I spent a fair amount of time experimenting with 4x6tb drives about 2 years ago and was unable to find a way around this with either the stock firmware or running debian.