HD-TGL will work with up to 500 GB drives. Those units are more temperamental as far as upgrading goes, you're best bet is to replace one drive at a time, restructuring the array between each replacement, until all four have been upgraded. Then, delete the raid, and create a new raid array. This SHOULD give you the ~1.4 TB capacity of 4 500 GB drives in RAID 5.... but as I'm sure you've noticed, upgrading drives is not supported... if it doesn't work, you're on your own.
TS-HTGL supports up to 2 TB drives. The best way to upgrade those drives is to replace all four at once, run the TFTP Boot Recovery, and a firmware update. Again, this is not supported, but I've seen it work in multiple cases.